Abstract
Comparison of genomic and EST sequences reveals a greater genetic diversity within eukaryotes than prokaryotes and enables identification of taxon-specific sequences.
Highlights
Systematic comparisons between genomic sequence datasets have revealed a wide spectrum of sequence specificity from sequences that are highly conserved to those that are specific to individual species
At least for eukaryotes, the overall sequence discovery rate' (OSDR) may be skewed by the close evolutionary relationships of some of the genomes sampled
Analyses of gene family discovery rates within different eukaryotic taxa revealed similar trends to those observed for sequence discovery rates (Additional data file 5). Together these results suggest that the observed differences in sequence discovery rates between the various taxa are not due to sequencing biases or lineage specific duplications, but rather reflect genuine differences in sequence diversity
Summary
Systematic comparisons between genomic sequence datasets have revealed a wide spectrum of sequence specificity from sequences that are highly conserved to those that are specific to individual species. Systematic comparisons of proteins and coding sequences from existing genome scale datasets from a wide variety of organisms [3] are beginning to yield insights into the generation and extent of sequence diversity across life [4,5,6,7,8,9]. In addition to the continued discovery of apparently novel genes and gene families with each new sampled organism, these studies are beginning to reveal a wide spectrum of sequence specificity. Sequences may be highly conserved across many different species from several evolutionarily distant lineages
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