The global dynamics of RNA stability orchestrates responses to cellular activation

Jack D Keene

doi:10.1186/1741-7007-8-95

Jack D Keene

Open Access

https://doi.org/10.1186/1741-7007-8-95

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Abstract

Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation. These changes arise from the opposing fluxes of transcription and mRNA decay, both of which affect the functional dynamics of global gene expression. A study published recently in BMC Genomics focuses on the contribution made by mRNA stability in shaping the kinetics of gene responses in mammalian cells.See research article http://www.biomedcentral.com/1471-2164/11/259

Highlights

Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation
It is useful to have this assumption further challenged by Agami and co-workers (Elkon et al.) [1], who examined on a global scale the role of mRNA stability in shaping the kinetics of gene responses
RNA decay is a rapidly growing field, but only recently have investigators begun to consider that global changes in mRNA stability can indicate systematic coordination across functionally related transcripts as governed by trans-acting factors [2]

Summary

Introduction

Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation. RNA decay is a rapidly growing field, but only recently have investigators begun to consider that global changes in mRNA stability can indicate systematic coordination across functionally related transcripts as governed by trans-acting factors [2].

Results

Conclusion