Abstract
Ochrobactrum species are non-enteric, Gram-negative organisms that are closely related to the genus Brucella. Since the designation of the genus in 1988, several distinct species have now been characterised and implicated as opportunistic pathogens in multiple outbreaks. Here, we examine the genus, its members, diagnostic tools used for identification, data from recent Ochrobactrum whole genome sequencing and the pathogenicity associated with reported Ochrobactrum infections. This review identified 128 instances of Ochrobactrum spp. infections that have been discussed in the literature. These findings indicate that infection review programs should consider investigation of possible Ochrobactrum spp. outbreaks if these bacteria are clinically isolated in more than one patient and that Ochrobactrum spp. are more important pathogens than previously thought.
Highlights
Gram-negative, non-fermenting bacteria are an emergent worry in medical situations and are becoming a growing cause of severe infections
Gram-negative, non-fermenting bacteria can infect both patients undergoing treatments and individuals outside of a clinical setting with various underlying conditions or diseases. Another type of these bacteria are the members of the α-proteobacterial genus Ochrobactrum [6]
Ochrobactrum spp. are very closely related to brucellae, and even though they are considered to be of low virulence, they have increasingly been found to cause infections in immunocompetent hosts [17,18]
Summary
Gram-negative, non-fermenting bacteria are an emergent worry in medical situations and are becoming a growing cause of severe infections. Pathogens of this type are opportunistic and include many different bacterial species, such as Ralstonia spp., Pseudomonas aeruginosa, Sphingomonas paucimobilis and Brevundimonas spp. Gram-negative, non-fermenting bacteria can infect both patients undergoing treatments and individuals outside of a clinical setting with various underlying conditions or diseases. Another type of these bacteria are the members of the α-proteobacterial genus Ochrobactrum [6]. Ochrobactrum spp. are very closely related to brucellae, and even though they are considered to be of low virulence, they have increasingly been found to cause infections (some serious including endocarditis and septicaemia) in immunocompetent hosts [17,18]
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