Abstract
The Curcuma genus has been extensively used for therapeutic purposes in traditional or folk medicine worldwide, including for its anti-inflammatory activity. Curcuma spp.’s active constituents, such as alkaloids, flavonoids, and terpenoids, can act on various targets in the signaling pathway, restrain pro-inflammatory enzymes, lower the production of inflammatory cytokines and chemokines, and reduce oxidative stress, which subsequently suppresses inflammatory processes. Preclinical and clinical studies have reported the predominant anti-inflammatory activity of several Curcuma species. This review provides an overview of the anti-inflammatory effects of different extracts, preparations, and bioactive components in this genus. This analysis may provide a scientific basis for developing new and alternative methods for the isolation of a single entity from this genus to attenuate inflammatory conditions. The Curcuma genus is waiting for researchers interested in developing safe and efficient anti-inflammatory agents for further investigation.
Highlights
Humans’ search for drugs from natural sources dates from ancient times and there is abundant evidence from various sources, such as written documents, preserved monuments, and even original plant medicines
The phenolic compounds known as curcuminoids display antioxidant activity that helps to inhibit the production of reactive oxygen species (ROS), resulting in anti-inflammatory properties because of the blockade of COX, LOX, nitric oxide (NO) synthesis, and other inflammatory enzymes, and disrupts the transduction of cellular signals through different mechanisms, including protein kinase C inhibition
The present review summarizes the anti-inflammatory properties of the genus Curcuma
Summary
Humans’ search for drugs from natural sources dates from ancient times and there is abundant evidence from various sources, such as written documents, preserved monuments, and even original plant medicines. People have been fighting against several diseases for many years, resulting in creating an awareness of medicinal plant usage They learned to pursue drugs from various plant parts, including barks, seeds, fruit bodies, as even the whole plant [1]. In every period, during every successive century from the development of humankind to advanced civilizations, the healing properties of certain medicinal plants have been identified, noted, and conveyed to the successive generations. This perpetual interest in medicinal plants for providing drug molecules has brought about today’s modern and sophisticated fashion of their processing and usage as lead compounds for drug discovery [1]. We presented the bioactive compounds, clinical, preclinical studies, and commercial perspectives of the Curcuma genus
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