Abstract
Objective: This work aimed of to review the implications of anti-TNF-α therapy in COVID-19 patients associated with the genetic polymorphism (TNF-α polymorphisms in the region-308) of this pertinent cytokine Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web of Science and The Cochrane Library with the aid of key-words. Results: Twenty-six articles were collected. Anti-TNF-α therapy was interpreted and evaluated. Conclusions: Although scarce information is available in the current literature, anti- TNF-α therapy seems to be a viable clinical approach for hospitalized COVID-19 patients who do not need oxygen supply. The genetic polymorphisms, although relevant, may be useful for further researched to assess the clinical response in different research groups.
Highlights
The process of inflammation in more complex and developed animals imply in the due communication of leucocytes and their communication, accomplished by cytokines and chemokines
The aim of this article was to research through literature review, whether Tumor necrosis factor-α (TNF-α) polymorphisms are able to modulate the clinical course of COVID-19 patients
Its pathogenesis is increased when the virus reaches the endothelial cells of the lungs, via attaching the ACE2 receptors located in the cell membrane therein; whose immunological reaction acts by hyperactivating macrophages and other immune cells, such as natural killer cells, stimulating cytokine and chemokine production and liberation 19,20
Summary
O Polimorfismo Genético do TNF-α Associado com a Terapia Anti- TNF-α Usada para Pacientes com COVID-19 – Outra Abordagem Possível. El Polimorfismo Genético TNF-α Asociado con la Terapia Anti-TNF-α Utilizada Para Pacientes. Received: 10/08/2021 | Reviewed: 10/15/2021 | Accept: 01/10/2022| Published: 01/12/2022. ORCID: https://orcid.org/0000-0003-4441-7601 Faculdade de Odontologia do Recife, Brazil
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