Abstract
This study was designed to investigate the mutagenic potentiality of the anticancer drug vincristine and fennel plant extract on Drosophilla melanogaster using two test systems, the sex linked recessive lethal (SLRL) and estimating the activity of cholinesterase enzyme (ChE) in F1 and F2 bar eye females and F2 wild types males. A wild type Strain Oregon-R (or-R) male flies of D. melanogaster were treated on a medium containing a concentration of one of individually of the two agents, followed by combined treatment in an alternative way of fennel extract followed by vincristin, then vincristin followed by fennel extract and finally the two agents together. The results showed no significant increase in the percentage of the S.L.R.L in all stages of spermatogenesis in all treatments. Meanwhile, vincristine and fennel plant extract showed a genotoxic effects in the three categories of the two generations of S.L.R.L, F1 females heterozygous F2 bar eye females and F2 wild type males on the genetic background of ChE in all treatments.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
