The Genetic Dissection of Complex Traits

Abstract

Genetic Dissection of Complex Traits Rao Table of Contents Contributors. Preface. Acknowledgments. NEWTON MORTON'S CONTRIBUTIONS Newton Morton: The Wisconsin Years. Newton Morton's Influence on Genetics: The Morton Number. OVERVIEW AND PRELIMINARIES Genetic Dissection of Complex Traits: An Overview. Familial Resemblance and Heritability. Linkage and Association: Basic Concepts. PHENOTYPES AND GENOTYPES Definition of the Phenotype. Genotyping for Human Whole-Genome Scans: Past, Present, and Future. MODEL-BASED METHODS FOR LINKAGE ANALYSIS The Lod Score Method. Extension of the Lod Score: The Mod Score. Major Strengths and Weaknesses of the Lod Score Method. MODEL-FREE METHODS FOR LINKAGE AND ASSOCIATION ANALYSIS Overview of Model-free Methods for Linkage Analysis. Variance Component Methods for Detecting Complex Trait Loci. Linkage and Association with Structural Relationships. The Future of Genetic Case-Control Studies. Cost of Linkage versus Association Methods. Genotype-Environment Interaction in Transmission Disequilibrium Tests. Major Strengths and Weaknesses of Model-free Methods. MORE RECENT METHODS Meta-analysis for Model-free Methods. Classification Methods for Confronting Heterogeneity. Applications of Neural Networks for Gene Finding. Genome Partitioning and Whole-Genome Analysis. Deciphering the Genetic Architecture of a Multivariate Phenotype. OPTIMUM STRATEGIES On the Resolution and Feasibility of Genome Scanning Approaches. One-Stage versus Two-Stage Strategies for Genome Scans. MULTIPLE COMPARISONS AND SIGNIFICANCE LEVELS Significance Levels in Genome Scans. False Positives and False Negatives in Genome Scans. Sequential Methods of Analysis for Genome Scans. CHALLENGES FOR THE NEW MILLENNIUM From Genetics to Mechanism of Disease Liability. Complex Inheritance: The 21st Century. Appendix: Research Contributions of Newton E. Morton. Index.