The genetic basis of ovarian cancer: Identifying hereditary ovarian cancer using a 25-gene panel

Abstract

Objectives: Ovarian cancer is represented in different hereditary cancer syndromes, including hereditary breast and ovarian cancer (HBOC) caused by mutations in BRCA1 and BRCA2 and Lynch syndrome (LS) caused by mutations in MLH1, MSH2, MSH6, PMS2, and EPCAM. Recently, mutations in other genes have been identified as increasing ovarian cancer risk, including RAD51C, RAD51D, and BRIP1. This analysis describes the genetic testing results for patients with ovarian cancer tested with a 25-gene hereditary cancer panel.