The genetic association of polymorphism rs2383207 in chromosomal locus 9p21, with coronary artery disease

Abstract

BackgroundThe 9p21.3 locus was associated with coronary artery disease (CAD). The aim of this study was to investigate the association between rs2383207 in chromosomal locus 9p21 with coronary artery disease based on positive angiographic findings [case group] compared with subjects without angiographic lesions [control group] in Arab subjects.MethodsBlood was drawn from a total of 176 patients and 210 control subjects. Genotyping of rs2383207 was performed by the 5’ nuclease assay using TaqMan assay.ResultsThe studied SNP was in Hardy–Weinberg equilibrium. CAD patients had significantly higher frequency of hypertension, higher glucose, CK‐MB and troponin level than controls. The frequency distribution of the genotype (rs2383207, G>;A) revealed that (64.4%), (54.3%), had GG and (32.1%), (37.9%) had GA, and (3.5%), (7.8%) had AA among CAD and control group, respectively with P value=0.137. The carriers of G allele of rs2383207 variant had a significant association with the risk of getting CAD, and the odds ratio “OR” and 95% confidence interval (95%CI) was 1.53 (1.16–2.24) times among CAD patients, with p value =0.04. To estimate the size of this association, the carriers of GG vs. GA+AA genotype of rs2383207 had the odds ratio and 95% CI of getting CAD with lesion (1.5, 1.1–2.9, p value=0.032).ConclusionOur finding confirmed a strong association of the rs2383207 in 9p21.3 locus with CAD in Arab populations.