Abstract
Aim. To assess the relation of polymorphism of the genes APOC3, PON1, AGT, AGTR1 and psychovegetative disorders in young, relatively healthy persons. Material and methods. Totally, 75 healthy volunteers included, white race, aged 20-25 y.o. Psychovegetative status was assessed with tests for panic attacks revealing, anxiety level assessment, as with the questionnaire for vegetovascular dystony. The inclusion criteria was organic pathology of cardiovascular and central nervous system. Genes polymorphism was identified with the method of pyrosequencing of desoxyribonucleic acid with the genetic analysis equipment “PyroMark Q24” Results. The presence of vegetovascular dystony, panic attacks and increased level of anxiety was mostly associated with the presence of T polymorphism -482 C>T gene APOC3, allele М polymorphism L55M А>Т gene PON1 and allele А — polymorphism А1666С А>С gene AGTR1. Conclusion. There is relation of genes polymorphism playing role in lipids metabolism and arterial pressure regulation, with psychovegetative status of the young, relatively healthy persons.
Highlights
The genes associated with lipid metabolism disorders and with blood pressure regulation, and psychovegetative changes in the young almost healthy persons
The presence of vegetovascular dystony, panic attacks and increased level of anxiety was mostly associated with the presence of T polymorphism -482 C>T gene APOC3, allele М polymorphism L55M А>Т gene PON1 and allele А — polymorphism А1666С А>С gene AGTR1
9. Mendivil CO, Rimm EB, Furtado J, et al Low-density lipoproteins containing apolipoprotein C-III and the risk of coronary heart disease
Summary
The presence of vegetovascular dystony, panic attacks and increased level of anxiety was mostly associated with the presence of T polymorphism -482 C>T gene APOC3, allele М polymorphism L55M А>Т gene PON1 and allele А — polymorphism А1666С А>С gene AGTR1. АД — артериальное давление, ВСД — вегетососудистая дистония, ДНК — дезоксирибонуклеиновая кислота, SNP — Single-nucleotide polymorphism (полиморфизм единичных нуклеотидов), PHQ — Patient Health Questionnaire Panic Screening Questions — Опросник для выявления панических атак. Наряду с этим очевидна вероятность “обратного” влияния ведущих факторов кардиоваскулярного риска на проявление психовегетативных расстройств, при этом данные расстройства, в частности — вегетососудистая дистония (ВСД),. Перспективным направлением в этом контексте является изучение генома человека и идентификация генов, мутации которых предрасполагают к развитию психовегетативных и сосудистых нарушений, и, в частности исследование влияния полиморфизма генов, участвующих в обмене липидов и регуляции АД, на вероятность развития подобных расстройств. В этой связи анализ полиморфизма нуклеотидов генов, ассоциированных с факторами кардиоваскулярного риска, при развитии психовегетативных нарушений может быть весьма интересен. Цель исследования — изучить связь полиморфизма генов APOC3, PON1, AGT, AGTR1 и психовегетативных нарушений у молодых, относительно здоровых лиц
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
