The Generalized Shwartzman Reaction Induced by a Single Injection of Endotoxin in Pigs Fed A Vitamin E Deficient Commercial Diet

Abstract

An experimental generalized Shwartzman reaction (GSR) induced in pigs by endotoxin from Escherichia coli has been reported previously (Teige et al. 1973, Quast 1973). The diet given to the pigs seemed to influence the outcome of the experiments. It has been found difficult to provoke GSR in pigs fed a commercial diet, even when the E. coli endotoxin is given as a single, relatively large dose or as 2 properly spaced doses (Teige et al., Nordstoga 1976). Quast induced the GSR by continuous infusion of endotoxin. In connection with 1 experiment in pigs, changes indicative of GSR were observed among a group of animals fed a commercial diet and receiving a small single dose of endotoxin. These observations are presented in this paper.