Abstract
Low levels of mRNA for the key adrenal steroidogenic enzyme, cytochrome P-450(11) beta, have been reported in the early stages of adrenal regeneration. To determine whether the defect in cytochrome P-450(11) beta gene expression is located in the adrenal zona fasciculata or glomerulosa, in situ hybridization techniques have been employed. Sections from 1 week regenerating adrenals were probed with sense and anti-sense cytochrome P-450(11) beta RNA. The signal was intense in the zona fasciculata cells in control adrenals but very low in those of adrenal regenerates. These data establish that the low levels of mRNA transcripts of cytochrome P-450(11) beta are localized to the zona fasciculata cells responsible for 11-deoxycorticosterone secretion in regenerating adrenals.
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