Abstract
Hypersensitivity to thermal and mechanical stimuli associated with tissue inflammation is caused in part by increased expression of the neurotrophic growth factors NGF and artemin (Artn). Artn expression increases 10-fold in skin inflamed by complete Freund's adjuvant (CFA) and the timecourse of this expression coincides with behavioral thermal hyperalgesia. The role of Artn in hypersensitivity was investigated using mice that overexpress Artn in the skin. Sensory ganglia of these mice exhibit transcriptional changes in TRPV1 (increased ~2-fold) and TRPA1 (increased ~4-fold).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
