Abstract
The ganglioside composition of three human bladder cell lines, two tumourigenic (RT112 and EJ138) and one non-tumourigenic (Hu609) were analysed by thin-layer chromatography and mass spectroscopy. Sub-confluent cultures of the three cell lines expressed mainly monosialogangliosides. Xenografts of EJ138 cells expressed nearly twice as much GM(3) as tissue cultured cells. Proliferation of Hu609 and EJ138 cells measured by H-3-thymidine incorporation was increased by GM(3) and further enhanced by addition of EGF. Paradoxically the migration of all three cell lines was inhibited by a mixture of monosialogangliosides and the inhibition was abolished by EGF.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
