The GABAB receptor antagonist CGP 36 742 and the nootropic oxiracetam facilitate the formation of long-term memory

Abstract

The memory-enhancing effects of a single treatment with the GABAB antagonist CGP 36 742 (10 mg/kg) or the nootropic agent oxiracetam (100 mg/kg) given immediately after a learning experience (‘post-trial’) remain detectable for at least 4 months thereafter. This indicates that in all probability these substances facilitate the formation of the long-term memory trace.