Abstract
Traumatic Brain Injury (TBI) research is evolving. The quest for level-1 evidence through randomised prospective interventional trials, while useful to establish safety and efficacy, is changing to an era of big data observational studies. Comparative Effectiveness Research (CER) utilises the observation of differences between treatments and centres without strict inclusion/exclusion criteria or formal intervention [1]. In addition, the transfer of monitoring technologies into the pre-hospital field will enable research into earlier, more critical phases of brain injury. These two changes in TBI research direction should enable a better understanding of the spectrum of TBI diseases and foster a future of precision, personalised TBI management.
Highlights
Traumatic Brain Injury (TBI) research is evolving
Global epidemic of TBI Trauma is the commonest cause of death in under 45s and TBI the commonest cause of this death [2]
TBI fails to attract research funding appreciated by more recognisable diseases such as cancer and heart disease
Summary
Traumatic Brain Injury (TBI) research is evolving. The quest for level-1 evidence through randomised prospective interventional trials, while useful to establish safety and efficacy, is changing to an era of big data observational studies. Comparative Effectiveness Research (CER) utilises the observation of differences between treatments and centres without strict inclusion/exclusion criteria or formal intervention [1]. The transfer of monitoring technologies into the pre-hospital field will enable research into earlier, more critical phases of brain injury. These two changes in TBI research direction should enable a better understanding of the spectrum of TBI diseases and foster a future of precision, personalised TBI management. In the US approximately 5.3 million live with disability following TBI. TBI fails to attract research funding appreciated by more recognisable diseases such as cancer and heart disease
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
