Abstract

AbstractA personal view of nearly four decades of structural chemistry is presented. The rise of molecular crystal engineering as an independent cross‐disciplinary field of research at the intersection of crystallography with supramolecular chemistry and solid‐state reactivity is discussed in light of the development of theoretical and instrumental tools and the need for novel molecular materials. The exchange of ideas and experience within the structural chemistry community has played a fundamental role in reaching the present high level of understanding of the factors that control crystal formation and stability. Crystal‐oriented synthetic strategies, including solvent‐free mechanochemical methods, have been developed, as well as screening methods and computational approaches. Some drawbacks and limitations are also discussed. The wealth of multiple crystal forms, from single‐molecule crystals to solvates, co‐crystals, salts and ionic co‐crystals, and their polymorphs, is both an open challenge to the crystal engineering paradigm and a source of discovery and innovation.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.