The future of imaging in drug discovery.

Abstract

The number of new chemical entities being registered by drug companies each year is declining, while at the same time, the number of new compounds, and thereby potential therapeutics, is increasing at an exponential rate. The need to demonstrate the safety, efficacy, and the “value” of these new compounds to a sophisticated pharmaceutical market, driven in turn by the forces of healthcare economics, make drug development difficult, resulting in a very lengthy and complex series of steps in the development of a drug. Many aspects of clinical pharmacology are more art than science, and detecting pharmacological effects at the level of living integrated systems is difficult. These challenges are most evident when developing new therapeutics for neuropsychiatric illnesses. We may at last be entering a postmonoamine era, exemplified by compounds such as NK-1 antagonists and metatropic glutamate receptor agonists. Such developments hold significant promise for the treatment of severe mental illness, while at th...