Abstract
Carica papaya (papaya) leaf extract has been used for a long time in a traditional medicine to treat fever in some infectious diseases such as dengue, malaria, and chikungunya. The development of science and technology has subsequently made it possible to provide evidence that this plant is not only beneficial as an informal medication, but also that it has scientifically proven pharmacological and toxicological activities, which have led to its formal usage in professional health care systems. The development of formulations for use in nutraceuticals and cosmeceuticals has caused this product to be more valuable nowadays. The use of good manufacturing practice (GMP) standards, along with the ease of registering this product facilitated by policies of the national government, will absolutely increase the value of papaya leaf extract as a vital nutraceutical and cosmeceutical products in the near future. In this article, we review the potential of papaya leaf extract to be a high-value commodity in terms of its health effects as well as its industrial benefits.
Highlights
In tropical and sub-tropical regions, there are abundant flora and fauna living in good climates and circumstances
This study provides consumers, manufacturers, and regulators of herbal products with the means to make decisions regarding the strategy of production of herbal medicine products according to the various good manufacturing practice (GMP) standards [121]
In conjunction with GMP, an herbal medicine product should be registered with the National Agency of Drug and Food Control following the consideration of the following factors, and, in so doing, it can be distributed across the globe: (1) the herb must be selected according to the relevant monographs published in its own country or with reference to the WHO monograph
Summary
In tropical and sub-tropical regions, there are abundant flora and fauna living in good climates and circumstances. One of the local products that is formulated as a herbal extract is papaya leaf extract, prepared in capsule dosage form, manufactured by Sido Muncul Industry, located in Semarang, Central Java, Indonesia, as a herbal and pharmaceutical product. In this product, the ingredient is claimed to be a food supplement that helps in weight gain and increasing appetite. The pharmacological and toxicological properties of papaya leaf extract will be discussed, even in terms of its molecular mechanisms, and, on this basis, new indications will be suggested
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