Abstract
Hantavirus, a genus of rodent- and insectivore-borne viruses in the family Bunyaviridae, is a group of emerging zoonotic pathogens. Hantaviruses cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome in man, often with severe consequences. Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis. This review summarizes the current knowledge on hantavirus interactions with hematopoietic and endothelial cells, and their effects on the increased vascular permeability.
Highlights
The fundamental role of endothelial cells in hantavirus pathogenesisReviewed by: Francisco Veas, Institut de Recherche pour le Développement, France Jochen Reiser, Rush University Medical Center, USA Peter T
TO HANTAVIRUSES AND THE ASSOCIATED DISEASE Hantavirus is a genus of rodent- and insectivore-borne viruses of the family Bunyaviridae
Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis
Summary
Reviewed by: Francisco Veas, Institut de Recherche pour le Développement, France Jochen Reiser, Rush University Medical Center, USA Peter T. Hantavirus, a genus of rodent- and insectivore-borne viruses in the family Bunyaviridae, is a group of emerging zoonotic pathogens. Hantaviruses cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome in man, often with severe consequences. Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis. This review summarizes the current knowledge on hantavirus interactions with hematopoietic and endothelial cells, and their effects on the increased vascular permeability
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