Abstract
The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia
Highlights
Bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), BA+COPD, and community-acquired pneumonia (CAP) are very common conditions
The reduction in lung tissue elasticity observed in severe BA may be related to an imbalance between oxidants and antioxidants and between proteolysis and antiproteolysis, which is accompanied by increased neutrophil elastase (NE) activity and is seen in COPD and CAP.[6]
Neutrophils, NE, AAT, phagocytic activity of neutrophils (PAN) and respiratory burst as related to pulmonary function: There was a negative correlation between increased neutrophil numbers and the AAT levels and spirometry flow scores (MEF50, FEF25-75%) in patients with mild BA, which confirms the negative link between inflammation severity and bronchial passability (p
Summary
To study the functional state of neutrophils in patients with bronchial asthma, bronchial asthma + COPD, COPD and community-acquired pneumonia to expand diagnosis, to determine the individual characteristics of the patients of the studied groups and choose the optimal methods of treatment
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