The functional state of rat brain mitochondria at the convulsive hypoglycemic syndrome and different ways of its correction

Abstract

Respiratory and phosphorylation functions of rat brain mitochondria were studied by the polarographic method under conditions of insulin shock in animals and after its treatment with glucose or glutamate (in combination with inhalation of air enriched with 7% CO2 as a hypercapnic gas mixture). Certain differences in the effects of the applied agents were found. Phosphorylation ability of mitochondria did not reach the normal level even one day after both ways of the convulsive state treatment. Some respiratory parameters suggest that unfavorable changes in the respiratory chain functioning mainly occur at the level of the respiratory chain complex I.