Abstract
The functional Ser326Cys polymorphism in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in gastric cancer risk. However, the published findings are inconsistent. We therefore carried out a meta-analysis to investigate this relationship. Nine published case-control studies, including 1180 gastric cancer cases and 2444 controls, were identified. Odds ratios and 95% confidence intervals were used to assess the strength of the association. Overall, the hOGG1 Ser326Cys polymorphism was significantly associated with an increased risk of gastric cancer in a recessive model (Cys/Cys vs. Ser/Cys+Ser/Ser: odds ratio=1.31, 95% confidence interval: 1.03-1.67). In the stratified analysis, a significant association was also observed among Asian populations and hospital-based controls. However, when stratified by smoking status of gastric cancer patients, no statistically significant result was found. Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism may contribute to susceptibility to gastric cancer.
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