Abstract
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.
Highlights
One of modern biology’s great surprises was the discovery that the human genome encodes only ~20,000 proteincoding genes, representing
Differential expression of long non-coding RNA (lncRNA) is becoming recognized as a hallmark feature in cancer, the functional role for the vast majority of these unique genes is still in question
We highlight characterized lncRNAs described to play a functional role in cancer-associated processes, such as metastasis and loss of imprinting
Summary
One of modern biology’s great surprises was the discovery that the human genome encodes only ~20,000 proteincoding genes, representing
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