Abstract
Abstract—The efficiency of phosphorylation in samples of isolated rat liver mitochondria in incubation media with variable isotopic composition at deuterium contents of 6, 60, 90, 120, 150 ppm, as well as 0.1, 1 and 2%, was studied. In media with a low deuterium content (up to 60 ppm), a monotonic decrease in the ADP/O ratio was observed, while at 6 ppm its value was the same as at 60 ppm. The generation of superoxide anion by complex I, II, and III of the mitochondrial respiratory chain was also investigated. For all studied modes of mitochondrial functioning using respiratory chain inhibitors, the generation of superoxide anion was independent of the deuterium concentration in the incubation medium.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
