Abstract
In the presence of severe exophthalmos it has been known that the basal metabolic rate, serum concentration of protein-bound iodine, and radioiodine uptake may be normal or compatible with either hypo- or hyperthyroidism. These findings have defied the clinician to relate exophthalmos directly to thyroid function. However, in a recent study of ten clinically euthyroid patients, Werner (1955) found all tests of function normal except for suppression of uptake by administration of triiodothyronine; here the patients with exophthalmos responded like thyrotoxic patients in that their uptake was not suppressed. In an attempt to elucidate further the function of the thyroid gland in clinically euthyroid patients with exophthalmos, eight such patients have been studied. Measurements included basal metabolic rates, serum concentration of protein-bound iodide (PBI), uptake of I131 by the thyroid, and the conversion ratio of I131 in serum (PBI131). Paper chromatographic analyses were made of the serum
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