Abstract
BackgroundVariations within fat mass and obesity associated (FTO) gene had crosstalk with obesity risk in European and some Asian populations. This study was designed to investigate FTO rs9939609 association with metabolic syndrome (MetS) as well as biochemical parameters as plasma glucose, serum triacylglycerol (TAG), total cholesterol (TC) and transaminases enzymes in Arab female population from Egypt.MethodsIn order to achieve that, FTO gene rs9939609 (A < T) was genotyped using TaqMan SNP Genotyping Assay in a total of 197 females which were enrolled in this study. Fasting levels of serum insulin, lipid profile and plasma glucose, in addition to liver transaminases were measured. The association between the genotype distribution and MetS risk was evaluated using Chi-square and logistic regression tests in a case-control design under different genetic models.ResultsThe association of genotype distribution with MetS was significant (χ2 = 8.6/P = 0.014) with an increased odds ratio under dominant model (OR = 1.97, P = 0.029 and 95%C.I = 1.07–3.6) and recessive model (OR = 2.95, P = 0.017 and 95%C.I = 1.22–7.22). Moreover, (AA) subjects showed significant lower HDL-C levels (P = 0.009) when compared to (TT) ones. In addition, interestingly subjects with (AA) genotype have significantly higher ALT levels (P = 0.02) that remained significant after correction of major confounders as body mass index and serum triacylglycerols but not after conservative Bonferroni adjustment.ConclusionsThe present study shows for first time that FTO gene rs9939609 is genetic risk factor for metabolic syndrome in Egyptian population which may help in understanding the biology of this complex syndrome and highlighted that this association may be through HDL-C component. The association of this genetic polymorphism with ALT levels needs to be studied in other populations with larger sample size.
Highlights
Variations within fat mass and obesity associated (FTO) gene had crosstalk with obesity risk in European and some Asian populations
Despite several studies showed association of FTO gene polymorphism with obesity in different populations mainly of European descent [12,13,14,15,16], this came in contrast with other studies in which the FTO polymorphisms do not associate with body mass index (BMI) or obesity risk in consistent manner as in many populations with different ethnicity [16,17,18,19]
Since the metabolic syndrome (MetS) is a complex disease, the cases and controls were chosen carefully to minimize the effects of other non-genetic risk factors and were matched for dietary habits and exercise levels through asked questionnaire including dietary habits and exercising levels
Summary
Variations within fat mass and obesity associated (FTO) gene had crosstalk with obesity risk in European and some Asian populations. This study was designed to investigate FTO rs9939609 association with metabolic syndrome (MetS) as well as biochemical parameters as plasma glucose, serum triacylglycerol (TAG), total cholesterol (TC) and transaminases enzymes in Arab female population from Egypt. Metabolic syndrome (MetS) is considered a major risk factor for cardiovascular diseases and stroke [1] in both developing and developed countries [2, 3]. Despite several studies showed association of FTO gene polymorphism with obesity in different populations mainly of European descent [12,13,14,15,16], this came in contrast with other studies in which the FTO polymorphisms do not associate with BMI or obesity risk in consistent manner as in many populations with different ethnicity [16,17,18,19]. It is highly possible that this variant, even it is not the true functional variant, is in linkage disequilibrium with true functional ones either within FTO gene or nearby genes [16]
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