Abstract
Follicle-stimulating hormone (FSH) is essential to folliculogenesis and acts through the FSH receptor (FSHR) present on the membrane of granulosa cells. Polymorphisms in the FSHR gene may lead to altered pattern of receptor expression on the cell surface or differential affinity toward FSH. The Ala307Thr polymorphism is located in the extracellular domain within the hormone binding region, which can influence the response to endogenous and exogenous FSH stimulation. Herein we investigated the association of this FSHR polymorphism with the ovarian response to exogenous recombinant FSH (r-FSH).
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