Abstract
The frequency of administration of combinations of antihypertensive drugs and its changes at different stages of observation was studied in 60 patients with difficult-to-control arterial hypertension (DTCAH) (32 men and 28 women) aged 59.0 ± 9.4. All patients were randomly divided into two subgroups: biofeedback (BFB) in the loop of paced breathing (PB) and heart rate variability (HRV) (33 patients) – basic subgroup, subgroup of comparisons (27 patients). Determined that patients with DTCAH in the subgroup of patients with the BFB in the loop of PB there has been a reduction of four-component antihypertensive therapy to three-component and in the subgroup of comparisons the frequency of the appointment of a four-component therapy was increased. At the same time, it was found that the addition of drug therapy with regular BFB sessions in the loop of PB contributed to the potentiation of the antihypertensive effect in patients with DTCAH. It is concluded that the BFB in the loop of PB and HRV can be used as a technology to improve the efficiency of control of blood pressure in patients with DTCAH.
Highlights
Treatment of difficult-to-control arterial hypertension (DTCAH) is an important problem due to the widespread prevalence of patients with DTCAH (30.4–31.8 % of the total population of patients with hypertension) [1], rapid progression of target organ damage and a high risk of cardiovascular events [2].DTCAH is characterized by the inability to achieve target blood pressure values, despite the appointment of three or more antihypertensive drugs, including diuretics [3]
The results show that the addition of antihypertensive therapy by BFB in the loop of heart rate variability (HRV) and paced breathing (PB) reduces the number of prescribed drugs
The addition of drug therapy with regular BFB sessions in the loop of PB contributes to the potentiation of the antihypertensive effect in patients with DTCAH
Summary
Treatment of difficult-to-control arterial hypertension (DTCAH) is an important problem due to the widespread prevalence of patients with DTCAH (30.4–31.8 % of the total population of patients with hypertension) [1], rapid progression of target organ damage and a high risk of cardiovascular events [2].DTCAH is characterized by the inability to achieve target blood pressure values, despite the appointment of three or more antihypertensive drugs, including diuretics [3]. Treatment of difficult-to-control arterial hypertension (DTCAH) is an important problem due to the widespread prevalence of patients with DTCAH (30.4–31.8 % of the total population of patients with hypertension) [1], rapid progression of target organ damage and a high risk of cardiovascular events [2]. Due to the absence of randomized clinical trials, the selection of therapy for persons with TAG occurs empirically, taking into account national recommendations for the treatment of hypertension [4]. The best treatment strategy in this case is to select a combination of antihypertensive drugs, which will affect the various links of pathogenesis and physiological mechanisms of hypertension, as well as take into account the comorbidity of a particular patient
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Schedule a callMore From: The Journal of V. N. Karazin Kharkiv National University, Series "Medicine"
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