Abstract
ObjectiveThe aim of this study was to evaluate the frequency of red blood cells (RBC) alloantibodies in surgical patients. Materials and methodsEighteen thousands nine hundred and eighty blood samples of Chinese patients who were undergoing surgery were collected and tested between January 2009 and September 2010. For patients with RBC alloantibodies, the sequences of antibodies were identified with the Diamed Asia antibody screen system. Data on gender, age, transfusion history, pregnancy history, and alloantibody specificity were collected. ResultsThirty-nine alloantibodies were identified from 18,980 samples. The prevalence of positive antibodies was 0.21%. The most frequently identified alloantibody was a RH system antibody (66.7%) (26/39) including: anti-E (16/39), anti-c (5/39), anti-cE (2/39), anti-e, anti-Cw, and anti-D (1/39 respectively). Other antibodies included anti-M (5/39), anti-Lea (2/39), and anti-Leb (1/39), anti-K+S (1/39), anti-Jka (1/39), and anti-Jsa (1/39). The frequency of alloantibodies in females was greater than that in males (31 vs 8). ConclusionThe results show a higher predominance of RBC alloantibodies in females than males. Anti-E is the most common alloantibody identified in the Chinese surgical population and is also more frequent in females compared to males.
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