Abstract
We studied the frequencies of human leukocyte antigen alleles (A, B, and DRB1) in 90 patients with acute lymphoblastic leukemia (ALL) and then compared them with 126 controls in this study. Although the frequencies of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and homozygosity of A*02 were higher in patients (p=0.006, p=0.003, p=0.002, p=0.01, and p=0.02, respectively), the frequencies of the A*23, B*13, B*40, and DRB1*13 alleles were lower (p=0.002, p=0.07, p=0.002, and p=0.003, respectively) in patients than controls. The frequencies of the DRB1*04 and DRB1*07 alleles were higher in patients in the high-risk group and standard-risk group, respectively (p=0.009 and p=0.007, respectively). This study indicated that the frequency of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and A*02 homozygosity may play a predisposing role in patients with ALL in the Turkish population. The frequency of the DRB1*04 and DRB1*07 alleles may also be associated with high risk and standard risk in patients with ALL, respectively.
Highlights
Acute leukemia is an uncontrolled clonal disease due to the increasing of immature hematopoietic cells with a rate of at least 25% in the bone marrow [1]
We studied the frequencies of human leukocyte antigen alleles (A, B, and DRB1) in 90 patients with acute lymphoblastic leukemia (ALL) and compared them with 126 controls in this study
This similarity for the DRB1*13 allele among studies may be explained by geographic proximity and interactions between Iranian [10] and Turkish populations [12]
Summary
Acute leukemia is an uncontrolled clonal disease due to the increasing of immature hematopoietic cells with a rate of at least 25% in the bone marrow [1]. Acute lymphoblastic leukemia (ALL) is the most common cancer in pediatric populations [2]. The incidence of ALL is about 30 cases per million persons younger than 20 years. It is the most common cause of death among cancers in children [3,4]. Human leukocyte antigen (HLA) genes encode cell surface glycoproteins associated with antigen presentation that selectively interact with short peptide fragments derived from
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Schedule a callMore From: Turkish journal of haematology : official journal of Turkish Society of Haematology
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