The frequency of hippocampal theta oscillations and unit firing can be manipulated by changing the t

Abstract

Event Abstract Back to Event The frequency of hippocampal theta oscillations and unit firing can be manipulated by changing the t Eva Pastalkova1* and Györgi Buzsaki2 1 HHMI, Janelia Farm Research Campus, United States 2 Rutgers University, CMBN, United States In order to study how theta oscillations organize the temporal patterns of neurons within the hippocampal-entorhinal system, we developed a method which allows us to manipulate the frequency of theta oscillations for short periods of time. We increased or decreased the local temperature within the medial septum using an insulated golden wire, which was connected to a Peltier device above a skull of an animal. We show that local cooling of the medial septum was followed by the decrease of the theta frequency and local heating by the increase of the theta frequency in both, hippocampus and entorhinal cortex. Correspondingly, firing of interneurons as well as pyramidal neurons and their interaction was faster during MS heating and slower during MS cooling. The change of the theta and unit firing frequency did not depend on whether an animal was running on a running wheel or in a maze suggesting that the firing of neurons is controlled by the theta oscillation rather than by the external sensory cues. Thus, heating and cooling of the medial septum can be used to manipulate the frequency of the theta oscillations in the hippocampus and entorhinal cortex, facilitating the study of the relationship between LFP oscillations, neuronal firing and sensory stimuli. Conference: Computational and Systems Neuroscience 2010, Salt Lake City, UT, United States, 25 Feb - 2 Mar, 2010. Presentation Type: Poster Presentation Topic: Poster session I Citation: Pastalkova E and Buzsaki G (2010). The frequency of hippocampal theta oscillations and unit firing can be manipulated by changing the t. Front. Neurosci. Conference Abstract: Computational and Systems Neuroscience 2010. doi: 10.3389/conf.fnins.2010.03.00072 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Feb 2010; Published Online: 19 Feb 2010. * Correspondence: Eva Pastalkova, HHMI, Janelia Farm Research Campus, Ashburn, United States, pastak@janelia.hhmi.org Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Eva Pastalkova Györgi Buzsaki Google Eva Pastalkova Györgi Buzsaki Google Scholar Eva Pastalkova Györgi Buzsaki PubMed Eva Pastalkova Györgi Buzsaki Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.