Abstract
Introduction: The staining pattern of HER2/Neu expression in urothelial bladder cancer has been established for more than a decade, and literature review of the past reveals a dismal prognosis in Her2/Neu expressed invasive urothelial carcinoma.
 Aims & Objectives: To determine the frequency of immuno histochemical expression of Her2/Neu in urothelial carcinoma of bladder.
 Place and duration of study: This descriptive, cross-sectional study was performed at the Department of Pathology, Combined Military Hospital, Quetta from 15th May 2017 to 14th November 2017.
 Material & Methods: A total of 89 patients with urothelial carcinoma bladder, from 20 to 60 years of age, irrespective of the gender were included. Patients with already immuno histochemistry report and taking radiotherapy were excluded. The immuno histochemical processing was done and results were interpreted for expression (positive/negative) of Her2/ Neu receptor.
 Results: The participants in this research ranged from 20 to 60 years old with an average age of 44.16± 8.27 years & male to female ratio of 1.6:1.38. One in every four (1.6:1) of the 89 (42.70 percent) individuals studied with urothelial carcinoma of the bladder cases were found to have over expression of Her2/Neu receptor.
 Conclusion: This study concluded that frequency of over expression of Her2/Neu in urothelial carcinoma of bladder is very high.
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