Abstract
Objective. To study the frequency of identifying DNA of human herpesvirus type 4 (Epstein-Barr virus – EBV) in different brain tumours. Materials and methods. Following the surgical resection, 89 samples of brain tumours were analyzed by real time PCR (“DNA technology” commercial kit) for the presence of EBV DNA. Results. EBV DNA was detected in about 40% of the samples of different brain tumours. The frequency of EBV DNA in the samples of extracerebral tumours was higher than in intracerebral glial tumours. EBV DNA positivity in benign gliomas was superior to that in malignant ones. The mechanisms of EBV infection of tumour cells in the brain and the role of EBV in stimulation of tumour growth have not been yet elucidated. Conclusion. EBV DNA is detected in the cells of brain tumours of different histology, prevalently in glial tumours.
Highlights
89 samples of brain tumours were analyzed by real time PCR (“DNA technology” commercial kit) for the presence of EBV DNA
EBV DNA was detected in about 40% of the samples of different brain tumours
EBV DNA is detected in the cells of brain tumours of different histology, prevalently in glial tumours
Summary
Изучить частоту выявления ДНК вируса герпеса 4 типа (вируса Эпштейна–Барр — ВЭБ) в ткани опухолей головного мозга. Установлено, что ДНК ВЭБ содержится в 40% образцов различных опухолей головного мозга, во внемозговых опухолях ВЭБ выявляли реже, чем в глиальных внутримозговых. ДНК ВЭБ чаще определяли в доброкачественных глиомах, чем в злокачественных. В ткани различных по гистоструктуре опухолей головного мозга с различной частотой выявляли ДНК ВЭБ — онкогенного вируса человека.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
