The Frequency of Anti-Aquaporin-4 Ig G Antibody and Oligodendrocyte Glycoprotein (MOG) in Neuromyelitis Optica Spectrum Disorders

Abstract

Neuromyelitis optica (NMO) is characterized by severe attacks of optic neuritis (ON) and longitudinally extensive transverse myelitis (LETM) with 3 or more vertebral segment spinal cord lesions observed on magnetic resonance imaging (MRI). Approximately 90% of the patients with NMO and more than half of the patients with NMOSD are positive for autoantibodies againstaquaporin-4 (AQP4). A proportion of patients with NMO or NMOSD remain AQP4 antibody negative despite the use of the best assays available on serum samples collected during an acute attack and before initiating any treatment.