Abstract
Since Frei 1 demonstrated that an antigen, made from sterile pus aspirated from previously unruptured abscesses, produced a reaction in patients with lymphogranuloma inguinale when injected intradermally, many attempts have been made to find other reliable sources for this antigen. Satisfactory antigens have been made by grinding up infected glands and periglandular tissues, and there have been reports of antigens made from pus from rectal fistulas occurring in patients with the late manifestations of this disease. This reaction is an important aid in the diagnosis of lymphogranuloma inguinale. It is now well known that mice can be infected with lymphogranuloma inguinale by intracerebral inoculation of material from early cases and that the infection can be passed through several generations. One of the means of determining whether an animal has been infected with the disease is by making an antigen from the brain tissue and testing this on patients known to
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