Abstract
Despite all the efforts to develop an ideal technology for cancer treatment, vital parameters such as reducing the adverse effect and improving treatment efficiency still require significant improvement. For this purpose, the rational design of smart stimuli-responsive and a fully biodegradable delivery system is of great significance. By using ZIF-8 nanoparticles as a sacrificial template, black phosphorous quantum dots (BPQDs) and S-Nitrosoglutathione (GSNO), a NO precursor, were successfully encapsulated into HKUST-1@MIL-100. In cancerous cells, the high GSH and ROS level trigger the sequential reaction to rebuild redox equilibrium and stimulate the continual production of NO and hydroxyl radicals. In virtue of this, the MOFs serve not only as carriers and contrast agents but also as the catalysts for generation of NO and ·OH, which realizes a maximum atomic efficiency. Finally, the nanosystem completely degrades to tiny molecules including the ligand, metal ions and phosphate and excreted from the body.
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