Abstract
The Fourth Dimension of Biochemical Pathways
Highlights
Even on a plain wall chart, the intricacies of a cell’s biochemical pathways can boggle the mind
A static map can’t depict the complexity of a subway system in motion, and a wall chart can’t capture the four-dimensional dynamism of a cell in action, because neither one captures the crucial dimension of time
They show that the time responses of upstream and downstream segments differ dramatically, and they go on to develop a mathematical model that predicts the response of the pathway to experimental perturbations
Summary
Even on a plain wall chart, the intricacies of a cell’s biochemical pathways can boggle the mind. A static map can’t depict the complexity of a subway system in motion, and a wall chart can’t capture the four-dimensional dynamism of a cell in action, because neither one captures the crucial dimension of time. They show that the time responses of upstream and downstream segments differ dramatically, and they go on to develop a mathematical model that predicts the response of the pathway to experimental perturbations.
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