Abstract
Objective: To prepare the Aconitum coreanum film-coating tablets,in order to provide a more convenient and effective formulation for treatment of atrial fibrillation.Methods:New direct compression excipients were used to screen a formulation with good flowability and compressibility.Aconitum coreanum alkaloids salt tablets were prepared by direct powder compression process,and then coated with thin film.Results: The optimized formulation displays a good flowability.The appearance,hardness,weight difference and disintegration time of the tablets were in line with the relevant requirements of Pharmacopoeia of the People's Republic of China(2010 edition).The hygroscopicity of the tablet was significantly decreased after film-coating.Conclusion: The hygroscopicity of Aconitum coreanum alkaloids salt tablets prepared by direct compression process and coated with opadry is decreased significantly.The preparation process is simple,practical,and suitable for industrial production.
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