The Formulation And Evaluation Of Metamizole Na Tablet With Porang Tubers(Amorphophallus Oncophyllus) Flour As A Binder

Abstract

Many farmers are interested in planting porang tubers, and with many farmers planting porang tubers, the price of porang tubers has decreased at harvest time. Porang tubers contain several ingredients: starch, Glucomannan, fibre, fat, protein, minerals and vitamins. Glucomannan content can be used as a tablet binder, thickener, gelling agent, film former, coating material emulsifier, and stabilizer. This study used the wet granulation method to determine the concentration of porang tuber flour as a binder in Metamizole Na tablets. Tablets were made into three formulations with varying concentrations of porang tuber flour, namely FI 5%, FII 7.5% and FIII 10%. Tablets were tested for tablet uniformity, hardness, friability, disintegration time, and dissolution. The data obtained were analyzed using Kruskal Wallis. The analysis showed that variations in the concentration of porang tuber flour had a different effect, based on the Kruskal Wallis analysis, which showed a significant value of 0.10 (p>0.05). The formulation with a good physical quality test is formulation III, with a tablet hardness value of 6.84 kg and a disintegration time of 5.74 minutes, almost close to the control (+) 14.27 kg and 6.38 minutes. The higher the concentration of porang tuber flour, the higher the tablet hardness and the longer the disintegration and dissolution time.