Abstract
Bovine articular chondrocytes, cultured as cell suspensions and monolayers, produced prostaglandin (PG) E 2 and PGI 2 (assayed as 6 keto PGF 1α), rather less PGF 2α and irregular quantities of thromboxane (Tx) B 2. Addition of foetal calf serum to the medium greatly stimulated PG production (a sixfold increase in PGE 2 and a twofold increase in 6 keto PGF 1α). Prostanoid production by cell suspension grown in serum-free medium generally plateaued after 24 hours. In the presence of 20% foetal calf serum, prostanoid production in long-term monolayer cultures increased during the first 6 days of culture. Levels of PGE 2α levels remained high. Indomethacin (10- 6M) inhibited chondrocyte PG production both in the presence and absence of added arachidonic acid (10- 4M). Prostanoids produced by chondrocytes may play a role in the modulation of cartilage metabolism in vivo .
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