Abstract
The in vitro DES conjugation reaction with glucuronic acid in golden hamster and rat liver homogenates has been made evident. The measurement of UDP-glucuronyl transferase activity has been done by photocolorimetric determination of DES consumed after an incubation period with the homogenate. DESGA has been chromatographically and enzymatically identified as a reaction product. A comparative study of activity in male rat, male, castrated male and female hamsters and in the same type of hamsters a week after a 25 mg DES pellet implantation, has been done. In absence of UDPGA there is practically no DES consumption in any one of the cases. Of all variables under study: sex, castration, implantation and species, only this last one determines DES consumption differences of high statistical significance. Hamster liver consumes six times as much DES as that consumed by rat liver. The role of liver in renal tumour processes in hamster by DES is discussed.
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