The flexural strength of orthodontic acrylic resin containing resveratrol nanoparticles as antimicrobial agent: An in vitro study

Abstract

This study aimed to evaluate how the addition of resveratrol nanoparticles (RNPs), which act as an antimicrobial agent, affects the strength of acrylic resin used in orthodontics. According to ISO 20795-1-2013, 76 cold cure acrylic resin samples (65×10×3.3mm) were prepared. The samples were divided into four groups (19samples in each group) based on RN concentrations added to 1mL acrylic monomer (0 for control, 256, 512, and 1024μg/mL). Flexural strength was assessed in megapascal (MPa) using a universal testing machine. Data analysis involved nonparametric Kruskal-Wallis analysis of variance and pairwise post-hoc Dunn's test. The flexural strength decreased as the concentration of RNPs increased, with the lowest value observed at 1024μg/mL (63.06±5.33MPa). The control group exhibited the highest mean of flexural strength (88.43±4.41MPa), followed by the groups with RNPs at the concentrations of 256μg/mL (82.69±4.41MPa) and 512μg/mL (76.02±4.59MPa). In conclusion, the addition of RNs to orthodontic acrylic resin had a dose-dependent impact on its flexural strength. Based on the findings, we recommend incorporating RNs at a concentration of 256μg/mL as an antimicrobial agent in orthodontic acrylic resin. However, further research is necessary to assess the long-term effects and clinical applications of this approach.