Abstract
In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extension has been challenging. Here, we collected a list of traditional Chinese medicines with potential longevity properties from pharmacopeias. By utilizing the mother enrichment program, we systematically screened these traditional Chinese medicines and identified a single herb, Psoralea corylifolia, that increases lifespan in Saccharomyces cerevisiae. Next, twenty-two pure compounds were isolated from Psoralea corylifolia. One of the compounds, corylin, was found to extend the replicative lifespan in yeast by targeting the Gtr1 protein. In human umbilical vein endothelial cells, RNA sequencing data showed that corylin ameliorates cellular senescence. We also examined an in vivo mammalian model, and found that corylin extends lifespan in mice fed a high-fat diet. Taken together, these findings suggest that corylin may promote longevity.
Highlights
2,3,12, Chia-Jen Wang[13], In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan
We found that the ethanol extract of P. corylifolia significantly increased viability based on mother enrichment program (MEP), suggesting that the ethanol extract of P. corylifolia may extend the replicative lifespan (RLS) of yeast (Fig. 1a)
We identified that the n-hexane fraction of the ethanol extract of P. corylifolia increased the yeast lifespan by 20% at 10 μg/ml (Fig. 1d)
Summary
2,3,12, Chia-Jen Wang[13], In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. By utilizing the mother enrichment program, we systematically screened these traditional Chinese medicines and identified a single herb, Psoralea corylifolia, that increases lifespan in Saccharomyces cerevisiae. We examined an in vivo mammalian model, and found that corylin extends lifespan in mice fed a high-fat diet. Taken together, these findings suggest that corylin may promote longevity. SIRT1 has been suggested to enhance mitochondria and alter metabolic rates to increase lifespan through its HDAC activity[5] Despite such extensive studies in the field of aging, the number of compounds identified by intervention testing programs that extend the lifespan in mice is very small[6]. Scientists have been eager to identify pharmaceuticals that can extend lifespan and prevent aging diseases throughout history
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