Abstract
The First Two Imported Cases of SARS-CoV-2 Omicron Variant - Tianjin Municipality, China, December 13, 2021.
Highlights
On December 10, 2021, Tianjin CDC received specimens from the 2 cases, sequenced using Illumina iSeq platform (Illumina, San Diego, CA, USA), and obtained the sequencing results on December 13
This variant was first reported to the World Health Organization (WHO) by South Africa
Preliminary laboratory data have shown that Omicron displayed a reduction of immune protection
Summary
On December 10, 2021, Tianjin CDC received specimens from the 2 cases, sequenced using Illumina iSeq platform (Illumina, San Diego, CA, USA), and obtained the sequencing results on December 13. As of December 14, 2021, 55 counties shared 4,265 Omicron genome sequences in the GISAID database [3]. A total of 40 amino acid mutation sites (A67V, T95I, Y145D, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, N856K, Q954H, N969K, L981F, H69del, V70del, G142del, V143del, Y144del, N211del, and 214insEPE) and at least 26 amino acid mutation sites (T19R, G142D, C361R, K424I, N439I, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, F497Y, Q498R, N501Y, Y505H, N679K, P681H, A701V, N764K, D796Y, N856K, Q954H, N969K, L981F, and P1069S) were detected in the spike protein of the strains from Patient A and B, respectively.
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