The first-trimester maternal serum cyclophilin A concentrations in women with complicated pregnancy as preeeclampsia

Abstract

BackgroundCyclophilin A (CyPA) is a potential mediator of inflammation. We assessed the predictive value of the first-trimester maternal serum CyPA concentrations for complicated pregnancy. MethodsThe first-trimester serum CyPA concentrations were quantified in 100 women with normal pregnancy and in 351 women with complicated pregnancy, including 102 pre-eclampsia women, 131 gestational hypertension (GH) women and 118 gestational diabetes mellitus (GDM) women. Its association with complicated pregnancy was ascertained using multivariate analysis. ResultsMedian CyPA concentrations were significantly higher in women developing complicated pregnancy as pre-eclampsia, GH or GDM than in women with normal pregnancy. CyPA concentrations were independently correlated with C-reactive protein concentrations in complicated pregnancy as pre-eclampsia, GH or GDM women. Serum CyPA and body mass index were independently associated with the development of complicated pregnancy as pre-eclampsia, GH or GDM. Serum CyPA possessed significantly high area under receiver operating characteristic curve. Meanwhile, CyPA significantly improved the predictive value of body mass index. ConclusionsSerum CyPA might be utilized as a potential inflammatory biomarker for complicated pregnancy and assessment of serum CyPA might aid in the prediction of complicated pregnancy.