Abstract
There is adequate information in the literature from which to conclude that the greatest opportunity for fetal salvage is the first Rh-sensitized pregnancy. Too many interpret this to mean that the first affected baby will be minimally or mildy involved. This report of 109 first affected pregnancies indicates that 20 per cent of the Rh-positive fetuses are severely involved, that as many as 10 per cent may require intrauterine transfusion, and that the perinatal mortality rate is 10 per cent. These data are presented to emphasize the necessity of careful antepartum assessment of the fetus during the first isoimmunized pregnancy.
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