The first report on epidemiology of oropharyngeal Kingella kingae carriage in Scandinavian children: K.kingae carriage is very common in children attending day care facilities in Western Norway.

Abstract

Kingella kingae colonizes the upper airways in children and has been recognized as the most common causative agent of osteoarticular infections (OAI) in children below 4years of age. This is the first Scandinavian study to investigate oropharyngeal K.kingae carriage in healthy children. From June 2015 to August 2016, we recruited 198 healthy children aged 11-14months from routine consultations at health promotion centers in Hordaland County, Norway for a cross-sectional study. After their parents had provided informed consent; demographic data were registered, and an oropharyngeal swab was collected. The oropharyngeal swab was analyzed with a real-time PCR assay specific to K.kingae targeting the RTX toxin locus. Results showed an asymptomatic carriage rate of 12.6%. A striking and highly significant difference was observed between the children that had started attending day care facilities as compared with children still being at home (33.33% vs 8.5%; p<0.001). K.kingae is prevalent in young children in Norway. This study emphasize that K.kingae should be considered an important etiological agent in OAI. Transmission seems to be facilitated in day care facilities. The correlation between oropharyngeal carriage and OAI needs to be further explored.