The first phytochemical investigation of Artemisia nujianensis: Eight new guaianolides and their anti-inflammatory activity

Abstract

The first phytochemical investigation of Artemisia nujianensis resulted in the isolation of eight new guaianolides (1–8) and six known analogs. Their structures were determined by extensive analysis of 1D and 2D NMR data, HRESIMS data, DFT NMR calculations, and X-ray diffraction studies. Some compounds were evaluated for their anti-inflammatory activities in LPS-stimulated RAW 264.7 cells. Compounds 5, 7 and 9 showed moderate inhibitory effects on LPS-induced NO production in RAW 264.7 cells, with IC50 values of 12.50 ± 0.21, 9.53 ± 0.14 and 6.85 ± 0.11 μM, respectively.