Abstract
Abstract Modification of the tamoxifen skeleton by a ferrocenyl unit, combined with lengthening of the basic O(CH2)nN(CH3)2 chain from n=2 to n=3, generates a new type of antioestrogen with unique properties. This molecule, 5, easily accessible via a McMurry coupling reaction, is indeed effective against the proliferation of breast cancer cells via both the α oestradiol receptor and its newly discovered β form. © 2000 Academie des sciences / Editions scientifiques et medicales Elsevier SAS alkene complex / antitumor agents / metallocenes / ferrocene / receptors / steroids
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